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HPMC Hydroxypropyl methyl cellulose CAS 9004-65-3 is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products. As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
Properties
1) Appearance: HPMC is a nonionic cellulose ether, white grayish-white powder or granule,odorless and flavorless, soluble in cold water, glacial acetic acid, ethanol, l and glycol, slightly soluble in depending on the degree of substitutions, practically insoluble in hot water, ethylene glycol and toluene. HPMC is dissolved in a mixture of 10% and 90% chloride to form colloidal solutions.
2) The solution of HPMC has surface activity, high transparency, and stable performance. When heated at certain temperature, the solution becomes cloudy or forms flocculent gel. However, the solution becomes clear again after cooling. Different types of HPMC have different gelation temperatures. The solubility varies with the viscosity. The lower the viscosity, the higher solubility it has. The different types of HPMC are different in some properties and their solubility in water is not affected by pH.
3) Particle sizes: 100% pass rate in 80 mesh.
4) Apparent density: 0.25-0.70 g/mL (usually about 0.5 g/mL),specific density 1.26-1.31mL.
5) Color change temperature:190-200°C; Carbonization temperature:280-300°C.
6) Surface tension:42-56 dyn/cm (2% aqueous solution).
7) The higher methoxy content in HPMC, the lower gelation temperature, and the higher solubility in water and surface activity.
8) HPMC has some other characteristics, for example, thickening property, pH stability, retention of water, excellent film-forming property, good disperse and adhesion ability.